OVERVIEW
The progressive decline in the ability
to maintain cellular homeostasis with age has been associated with dysfunctional organelles in a tissue-specific manner.
Since organelles are regulators of central longevity pathways, understanding how the physiology of organelles changes with age would help not just to better understand age-related processes but also to uncover potential novel interventions with a yet unknown potential to improve age-related dysfunctions.
RESEARCH
Our Main Goals
and Questions
01.
How do organelles change with age?
02.
How do changes in organelles affect cellular pathways in a tissue-specific manner?
03.
Identify organelle-related pathways and proteins as potential therapeutic targets to improve age-related deterioration.
Model Organism
We use C. elegans, which is a powerful model organism for studying aging. We will initially study these questions in the context of the female reproductive system since this is the first phenotype associated with aging in humans.
Organelles and Beyond
By integrating various approaches, we will study reproductive aging at multiple levels, including organelle, cellular, tissue, and whole organism levels.
Research Approach
We apply molecular and biochemical methods to understand how organelles change with age and how these changes affect cellular pathways in a tissue-specific manner.
Our Main Techniques
OUR UNIQUE VALUE
As the maternal age for first childbirth has risen in recent years, understanding the mechanisms that regulate reproductive aging has become increasingly important.
Understanding how organelle dysfunction contributes to age-related deterioration may have implications for multiple tissues beyond the reproductive system and holds promise for identifying novel therapeutic strategies to combat age-related dysfunctions.
LATEST PUBLICATIONS
Enhanced Branched-Chain Amino Acid Metabolism Improves Age-Related Reproduction in C. elegans
